PYRIDOXINE DEFICIENCY IN HUMAN BEINGS INDUCED WITH DESOXYPYRIDOXINE 1

The effect of pyridoxine deficiency induced by desoxypyridoxine on acute lymphatic leukemia of adults.

I N PYRIDOXINE DEFICIENCY, there is an absolute decrease in the isumber of circulatitsg lymphocytes of dogs,’ monkeys,2 rats,3 atsd mice.4 In addition, lymphoid atrophy alsd regression of lymphosarcoma occurs its rats,’ although atrophy of lymphoid tissue its tsormal mice atsd modification of the lymphoid component of the leukemia of Ak mice was not observed.4 Treatmeust of lymphosarcoma and ac...

TyrosinerniaInducedby a Pyridoxine Antagonist , Desoxypyridoxine

Utuversity of Alberta Hospital, Edmonton 61, Alberta, Canada. For reprints, write D. J. C., Division of Clinical Chemistry, Department of Pathology, Vancouver General Hospital, Vancouver, B. C., Canada. ‘Nonstandard abbreviations used: not’, 4-desoxypyridoxine; pHPPA, p-hydroxyphenylpyruvic acid; PHPAA, p-hydroxyphenylacetic acid; pHyLA, p-hydroxyphenyllactic acid; VMA, vanillylmandelic acid (4...

Effect of pyridoxine and desoxypyridoxine on rat fibrosarcoma grafts.

Several reports in the literature on induced and transplanted tumors suggest that vitamin Be may be a factor of importance relative to incidence and growth of induced and transplanted tumors. When the Flexner-Jobling carcinoma was implanted in rats partially deficient in pyridoxine, the percent age of takes was lower (66 versus 85 per cent), the number of regressions higher (30 per cent versus ...

Pyridoxine deficiency in children treated with isoniazid.

Isoniazid-induced deficiency of pyridoxine (vitamin B6) is reportedly not uncommon in adults but rare in children. In the present study, 38 children had serum levels of pyridoxine tested while receiving therapy with isoniazid. A biologic assay using the protozoan Tetrahymena thermophila determined pyridoxine status after 2 to 18 months of therapy with isoniazid. Five children (13 percent) were ...

Brucella Infection Causing Abortion in Human Beings